Lasix is a fast acting diuretic, which in its chemical structure is a sulfamide derivative. To the reader immediately understood what is at issue – this is the original furosemide drug from the world pharmaceutical corporation “Sanofi Aventis”. The mechanism of diuretic action of the lasix consists in inhibiting the reabsorption (re-absorption) of sodium and chlorine ions in the renal tubules. Thus, the body more readily part with sodium (with chlorine too, but the first has much more clinical significance), which results in a cascade of secondary effects: an increase in the volume of excreted urine, increased excretion of potassium, calcium and magnesium ions. It is characteristic that with repeated administration of lasix its diuretic activity does not weaken. In patients with chronic heart failure, the drug in the shortest time reduces preload (this is due to the expansion of the vessels of the venous bed), “strikes steam” (read: reduces pressure) in the pulmonary artery and the left ventricular chamber. The urgency of its pharmacological effect, experts believe, is due to prostaglandins, so the necessary condition for the drug to turn “to its fullest” is the normal functioning of the prostaglandin system, as well as the adequate work of the kidneys. Lasix has an antihypertensive effect based on the increased excretion of sodium from the body, increased diuresis and the associated decrease in the volume of circulating blood, a decrease in the sensitivity of the smooth muscle walls of the blood vessels to vasoconstrictive effects. In the latter case, we are primarily concerned with catecholamines: due to the increased sodium excretion, Lasix softens the increased (as is typical of hypertensive) reaction of the vessels to these powerful vasoconstrictors. As shown by clinical studies with the participation of healthy volunteers, diuretic and saluretic action of lasix is observed when taking the drug in the range of 10 to 100 mg.
After parenteral administration of 20 mg of the drug, the diuretic effect began to appear after 15 minutes and lasted about 3 hours.
The manufacturer has mastered the production of two medicinal forms of lasix: tablets and solution for intravenous and intramuscular injection. Treatment with lasix is recommended to be performed using the lowest effective doses of the drug. It should be noted dose-dependence of the therapeutic effect of the drug, and also to mention that the lasix has a very high pharmacological “ceiling” (its activity rises in a wide range of doses). Despite the stated two ways of parenteral administration (intravenous and intramuscular), the second one is used only in exceptional cases when it is not possible to inject the solution into a vein or use a pill. Similarly, the intravenous and oral route of administration is correlated: the injection is performed only in situations when for some reason it is impossible to take the drug inside, there are violations of absorption of furosemide in the small intestine, or it is necessary to obtain a therapeutic effect very quickly. When using the injection form of lasix, it is recommended that the patient be transferred to a tablet form as soon as possible. Before the beginning of pharmacotherapy, it is necessary to exclude the presence of pronounced violations of urodynamics (urine outflow). During the treatment, it is desirable to monitor the concentrations in the blood of sodium, potassium, and also creatinine. Particularly careful monitoring should be carried out for patients prone to disturbances in the water-electrolyte balance (which can be caused by diarrhea, vomiting, or intense hyperhidrosis). During the drug course, it is recommended to enrich your diet with potassium, for which the menu includes products such as lean meat, tomatoes, cauliflower, spinach, potatoes, bananas, dried fruits, etc. Sometimes, depending on the situation, you may need to take potassium preparations.